My wife has been on Donepezil for a couple of years now; hard to tell if it's helping, as there is no control. However, one warning. She started on, I think, 10 mg per day, but this turned out to be slowing her heart rate, and a year ago she got up in the night for a pee and collapsed, fracturing three lumbar vertebrae, which was not fun. GP reduced dose to 5mg, which seems not to be causing problems. However, a week or so ago GP suggested trying a different drug (can't remember(!) the name) and we are waiting for a phone call tomorrow to see what to do.