Hi everyone, My poor Mum is going through a hard time at the mo. She is 87 and recently been diagnosed with mixed dementia (vascular and alzheimers), probably mild to moderate. She has been prescribed 5mg donepezil. I was very hesitant in agreeing to this medication but was persuaded to try so have gone ahead. From day 1 she has experienced horrible general malaise, mostly stomach related with pains in head, frequent urination and loss of appetite. This has got worse over the following days until day 5 (yesterday) she was really sobbing and wanting to die because she felt so terrible. The strange thing is that she has short periods when she is fine,well maybe not 'fine' but certainly much better. Tonight we are back to crying and feeling terrible and not wanting to go on like this. She has only taken the Donepezil for 5 days and has not taken any now for 48 hours. Has anyone else experienced these effects and can anyone tell me how long side effects last after coming off this drug? I don't know how to help her and I am at my wits end as my doctor just passes it off as anxiety. Thankyou for reading.