Good Afternoon lovely people. I wonder if anyone has any knowledge, or advice regarding Omezaprole. My husband has been prescribed this drug as he takes aspirin and blood pressure medications and he also suffers with acid reflux. He is waiting for an appointment for the memory clinic. A family member who works in a pharmacy has advised that it can cause memory problems. I wonder if anyone else is aware of this with Omezaprole.
Omezaprole.
- Thread starter Shem56
- Start date
My wife with LBD took aspirin and also had a sliding hiatus hernia, I queried the use of omeprazole because of mixed reports regarding dementia.
No mention, other than B12, in
www.medicines.org.uk
and
For instance, omeprazole led to deterioration of visual and episodic memory, motor and mental response speed, new learning, short-term and sustained attention, retention and manipulation of visuospatial information, and strategy development
www.ncbi.nlm.nih.gov
The result was carry on, it was needed because of the hernia and to counteract effects of aspirin on the gastric system.
No mention, other than B12, in
Losec Capsules 10mg - Summary of Product Characteristics (SmPC) - (emc)
Losec Capsules 10mg - Summary of Product Characteristics (SmPC) by Neon Healthcare Ltd
and
For instance, omeprazole led to deterioration of visual and episodic memory, motor and mental response speed, new learning, short-term and sustained attention, retention and manipulation of visuospatial information, and strategy development
Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences
Alzheimer's disease (AD) is the most common type of dementia, mainly encompassing cognitive decline in subjects aged ≥65 years. Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological ...
www.ncbi.nlm.nih.gov
The result was carry on, it was needed because of the hernia and to counteract effects of aspirin on the gastric system.
The number of studies done on this subject might tend to suggest there is some connection with PPI’s and impairment of cognition, but as yet nothing that definitively proves it. All drugs carry some risk of side effects, so you have to weigh up the risks versus the benefits as best you can.
I did see one Swedish study that said these drugs are safe but should be used with care for the cognitively impaired - lowest effective dose and only as necessary. But as always with these things they say more research is needed.
I did notice that one of the American studies mentioned that people can stay on medications for much longer than necessary, which I think is a fair point. Repeat prescriptions with little or no monitoring of symptoms is certainly common in my own experience.
edit: for clarification added the words “these drugs are safe”.
I did see one Swedish study that said these drugs are safe but should be used with care for the cognitively impaired - lowest effective dose and only as necessary. But as always with these things they say more research is needed.
Newly discovered mechanism can explain increased risk of dementia
Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that how the long-term use of these drugs could increase the risk of developing dementia...
www.sciencedaily.com
I did notice that one of the American studies mentioned that people can stay on medications for much longer than necessary, which I think is a fair point. Repeat prescriptions with little or no monitoring of symptoms is certainly common in my own experience.
edit: for clarification added the words “these drugs are safe”.
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I think we will stick with Gaviscon only for now. I've also seen that constipation could be caused with acid reflux and my husband does suffer badly with that also.The number of studies done on this subject might tend to suggest there is some connection with PPI’s and impairment of cognition, but as yet nothing that definitively proves it. All drugs carry some risk of side effects, so you have to weigh up the risks versus the benefits as best you can.
I did see one Swedish study that said these drugs are safe but should be used with care for the cognitively impaired - lowest effective dose and only as necessary. But as always with these things they say more research is needed.
Newly discovered mechanism can explain increased risk of dementia
Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that how the long-term use of these drugs could increase the risk of developing dementia...www.sciencedaily.com
I did notice that one of the American studies mentioned that people can stay on medications for much longer than necessary, which I think is a fair point. Repeat prescriptions with little or no monitoring of symptoms is certainly common in my own experience.
edit: for clarification added the words “these drugs are safe”.
my husband and i take lansoprazole which is another anti-acid. ive taken it for years on maximum dose and ive never had a problem with it.
