I don't write as much these days as I used to, but I do have concerns over how Donanemab is being sold by the media and the AS for that matter. This is not going to be a new wonder drug that many seem to think it is and I would err on the side of caution if anyone is hoping for a miracle just yet. Meta-analysis shows that Donanemab did not achieve clinically meaningful significance on all of the dementia tests used in the trials.
Source: VILLAIN, N., PLANCHE, V. & LEVY, R. (2022) High-clearance anti-amyloid immunotherapies in Alzheimer's disease. Part 1: Meta-analysis and review of efficacy and safety data, and medico-economical aspects. Revue Neurologique, 178(10), 1011-1030. Available online: https://www.sciencedirect.com/science/article/pii/S003537872200738X?via=ihub [Accessed 10/05/2023].
Over on the right are the Forrest plots, whilst they show treatment was favored, they also show they did not achieve clinical significance (the small bar like red lines)
It is questionable given the likely short term use of this drug whether it really has any benefit at all other than possibly buying some time for some people. There are more new therapies in the pipeline that have greater potential. As
@Jaded'n'faded also pointed out, there is no way of facilitating the use of this drug currently as the resources just don't exist.
I just like most people am desperate to see a new treatment for Alzheimer's, but equally it has to do as it says on the tin.