Early detection of dementia with default-mode network effective connectivity

[nitram]

Altered functional connectivity precedes structural brain changes and symptoms in dementia. Alzheimer’s disease is the largest contributor to dementia at the population level, and disrupts functional connectivity in the brain’s default-mode network (DMN). We investigated whether a neurobiological model of DMN effective connectivity could predict a future dementia diagnosis at the single-participant level.

https://www.nature.com/articles/s44220-024-00259-5 .