Hi, My mum was diagnosed about 3 years ago and put on Aricept and doing well on it. But in the last couple of weeks she has deteriated dramatically. Stopped doing crosswords, aggressive towards me, thinks the tv and photos can see her. She is also not sleeping. Now she did have a urine infection a few weeks ago but since then culture tests done by the hospital suggest this has gone. She was on three rounds of antibiotics. I ended up purchasing the Siemens urine dip strips and these indicate a high level of leukocytes in the urine which I thought indicated infection. I have tested it on myself and all fine so the strips appear to be working. The doctors won't prescribe antibiotics now, understandbly as they might not be the right ones or something else is going on. I have not slept for two weeks, sleeping pills seem to make her worse. I am now at my wits end and struggling with how nasty she is being to me. It's so awful, if she only knew what she was doing she would be mortified. It seems to kick in late in the evening, her eyes suddenly bulge. It's like the hulk Although today it's happening this morning, I know it's coming and as a result I'm on edge the whole time and feeling deeply depressed, worryingly so. I don't know what else to do. I'm normally really resilient but totally struggling with the inability to apply logic with her.