I feel as if I have kept most of the pharmaceutical companies going with all the different medications that were prescribed for Jan. The one with the most immediate adverse effect was Seroxat, an anti-depressant prescribed for Jan by one of a group practice when our GP was on holiday. Almost immediately after starting the pills, Jan started violent twitching. I took her off the medication immediately and she seemed to return to normal within hours. As has been the case right through, I have had to come to conclusions and make decisions that no-one else seemed capable of doing and the responsibility is crushing. Later, another doctor told me the Seroxat dose prescribed was way too high.