OK <phew!> back from my perusal of the BMJ article.....
All the subjects, for a start had 'a diagnosis of possible or probable Alzheimer's Disease'. The terms 'dementia' and 'Alzheimer's Disease' were used, from the initial specificity of this mission statement, interchangeably throughout the research report <tut tut!>
And all subjects in the research were suffering from SEVERE dementia.
In the end, 26 were on quetiapine, and 29 on the placebo (along with 25 on the 'typical' antipsychotic which has the known side effect of contributing to strokes. Quetiapine is an atypical antipsychotic)
The dose was 100 mg per day quetiapine, increasing from 50mg from week 12 to week 26.
So what, in summary, does the research paper say?
It says that in SEVERE stages of ALZHEIMER'S DISEASE, on a small sample basis, the MAXIMUM dosage of quetiapine can appear to worsen the condition, and doesn't apparently help with agitation either. We are talking here about those admitted to Nursing Homes because of the severity of their AD.
The ones who did best were those on placebos, and this is accounted for by the Hawthorne Effect - people like to take part in social activities, even if they're research projects, as it gives them an outlet for their sociability, and therefore they improve.
So, in summary, this paper has little to say to us, the in-house carers looking after those with moderate dementia, which may not be 100% Alzheimer's, and trying to deal with aggressive behaviour for which a smallish dose of quetiapine has been presecribed.
It's very specific paper targetted to the medical profession, and basically saying that when Alzheimer's (only) becomes severe, don't put your patients on anti-psychotics, typical or atypical, because at that stage, they really won't help, and maybe they'll even hinder.
It's not quite what the BBC is trying to make it out to be, is it? Ah well. Seek the sensational headline was always the motto of the red-tops. I, for one, hate to see that callous and cynical disregard for the whole truth moving into the BBC agenda.