When my husband`s diagnosis was given in September 2005, his MMSE score was 23. The following score was 20, and then 19, which was in November 2006. In November 2006, after reading that blood tests in people with Alzheimers showed a deficiency of B vitamins, B6, B9 [folic acid] and B12, he started to take them, with Vit E, which was reccommended to aid the metabolism of the Bs. Although we have had many ups and downs, coping with his condition and related behaviours, he has said he felt sharper, and I have noticed some improvements, including sleeping well all night, waking refreshed every morning, and not sleeping during daytime. Last Thursday he went for another consultation and assessment. He scored 20, on the MMSE test. The consultant was pleased with the score, but regarded it as the same as last time. To us, it was 1 point higher, instead of ? points lower. Now we must wait to see if this very slight improvement is giving us false hope, or if there really is some benefit in supplements. I will keep you posted.