Hi all, My husband has been on donepezil for nearly 10 months now and he has intermittently suffered from diarrhoea throughout that time. Actually the diarrhoea predates the donepezil although I think it may be making it slightly worse. Our GP said that it was unlikely to be caused by the donepezil after this length of time and he referred him for a colonoscopy which hasn't shown anything up. The last communication we had from our GP indicated that he thought the problem was therefore 'constitutional'. However we visited the memory clinic last week and the consultant there has picked up on the issue with the diarrhoea and said she thought we should take my husband off donepezil. I'm reluctant to just do this, especially as he is on a clinical trial for a drug which is intended to boost the effects of donepezil so it would mean coming off that trial as well. She initially said we could just stop the donepezil for a few days and see if it made a difference but I thought I have read somewhere that you shouldn't just come off it. She then said we could try alternative but similar drugs but this would presumably invalidate the clinical trial. She dismissed this and said there would be other trials he could get on, but it's taken a lot of work to get onto this one! I must admit that I don't feel I can really trust her advice - especially as when I asked her about genetic testing she said to me that she couldn't see the point as why would anyone want to know if they had an increased risk of developing alzheimers as there's nothing that can be done! I feel we are getting a bit caught between different bits of the medical profession here, each giving slightly contradicting advice. The diarrhoea he is living with and controlling with the occasional immodium so I'm reluctant to explore changing his medication and the consequent withdrawal from the clinical trial unless we really have to. Anyone else had similar experiences?