Kriss
this any good?
SEROQUEL AstraZeneca
Quetiapine
Use:
Antipsychotic agent for the management of the manifestations of schizophrenia. Adults, initially, 25 mg twice daily, titrated with 25-50 mg increments twice daily, as tolerated to a target dose of 300 mg/day given twice daily within 4 to 7 days. Make further dosage increments/decrements of 25-50 mg twice daily if indicated based on individual clinical response and tolerability at intervals of not less than 2 days. Usual effective treatment dose range: 300-600 mg/day. Some patients will require as little as 150 mg/day. Safety of doses> 800 mg/day not evaluated.
Elderly patients: consider a slower dose titration rate and a lower daily therapeutic target dose than that used in younger patients.
Mild hepatic impairment: Initially, 25 mg/day, with daily increments of 25-50 mg to an effective dose, depending on individual clinical response and tolerability.
Seroquel's efficacy in long-term us (i.e. > 6 weeks) has not been systematically evaluated in controlled trials.
Precautions:
Neuroleptic malignant syndrome, tardive dyskinesia. Hypotension and syncope, especially during the initial dose titration period. Conduct eye examinations prior to or shortly after starting Seroquel and at 6-month intervals thereafter; discontinue the drug if clinically significant lens changes are observed. History of seizures. Hypothyroidism. Hyperprolactinemia. Antiemetic effect. Suicide. Use with great caution immoderate or severe hepatic impairments. Renal impairment, cardiovascular disease. Disruption of body temperature regulation. Hyperglycemia. Lactation (avoid breast-feeding). Pregnancy: weight expected benefits vs. possible risks. Safety/efficacy in patients < 18 years not established.
Side effects:
Somnolence, dizziness, dry mouth, constipation, dyspepsia, postural hypotension, elevated ALT (SGPT) levels, weight gain.
Interactions:
May enhance the effects of other centrally-acting drugs, certain antihypertensive agents; may antagonize the effects of dopamine agonists and levodopa. Increased clearance of Seroquel by phenytoin, barbiturates, rifampin, carbamazepine. Increased concentrations of Seroquel with azole antifungals and macrolide antibiotics.
Patient tips:
Caution re somnolence, dizziness (NB driving). Avoid alcoholic beverages. Eye examinations as scheduled.
Supplied:
25 mg, 100 mg, 150 mg, 200 mg, 300 mg tablets
Now can we get on the drinking the wine? please
Lots of love
Dr Chesca