Welcome to the Group Robbie Rainbow ?, hope you find it helpful. My OH has PCA too, he has been on Donepezil for about4 years now, and for home it did slowly make a difference, his speech improved and also his confidence levels. I think what helped most though was he isn’t so depressed, we went on some holidays and visited friends and family and he gradually realised life was still worth living. He responds really well to music and we went to a few concerts/shows at our local theatre, it gave him a real lift. 4 years on his memory, confusion and anxiety are worse but in many ways he is better, people who don’t know often just think he’s a bit eccentric. But - I have had to change loads!! Good luck, if things don’t improve maybe some antidepressants might help, but I would try to get her involved in some things she used to really enjoy- maybe you could rope in some friends or family to help. Though I find my OH copes better with people in ones or twos.