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  1. #16
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    I wonder if it is taken in conjunction with other drugs this contributes to instability and falls, Kevin. I refused to let John have Respiridone when things were bad and we rode that one out. The higher doses of the Trazadone seemed to suit him better.

  2. #17
    Registered User Kevinl's Avatar
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    Given that there's several of us posted that we've used it then it does make you wonder about the claim "a drug to stop all neurodegenerative brain diseases, including dementia." as it doesn't seem to have worked for any of us.
    Don't they know this drug is already being regularly prescribed to people with AZ and I can assure them it didn't stop anything, she continued to decline but less aggressive and more wobbly.
    It might well work in mice but I can assure them it did nothing for my wife so if "Prof Mallucci said: "It's time for clinical trials to see if there's similar effects in people and put our money where our mouth is." I'll bet him a tenner it doesn't work.
    Come on Prof PM me with the odds you want
    K
    If you're going through hell, keep going

  3. #18
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    Quote Originally Posted by Kevinl View Post
    Given that there's several of us posted that we've used it then it does make you wonder about the claim "a drug to stop all neurodegenerative brain diseases, including dementia." as it doesn't seem to have worked for any of us.
    Don't they know this drug is already being regularly prescribed to people with AZ and I can assure them it didn't stop anything, she continued to decline but less aggressive and more wobbly.
    It might well work in mice but I can assure them it did nothing for my wife so if "Prof Mallucci said: "It's time for clinical trials to see if there's similar effects in people and put our money where our mouth is." I'll bet him a tenner it doesn't work.
    Come on Prof PM me with the odds you want
    K
    Kevinl, I think the -the academics/doctors - think that it has to be a combination of Trazadone And DBM ( the 'new' drug) that will be most effective.

  4. #19
    Registered User Lawson58's Avatar
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    Twenty years ago, a friend whose wife had been diagnosed with dementia told me that doctors had said that a possible cure was only two years away and that he was hopeful of some help being available for his wife. She has of course since passed away.

    We all know that there are numerous research programs and studies regarding dementia being undertaken, all promising that they might have something positive to contribute to those suffering with these dreadful diseases.

    Considering that there are over 100 different diseases that can cause dementia, that even diagnosis is still highly debatable and not particularly accurate, that realistic applications of all theses developments are always years away 'following clinical trials',is it any surprise that we are somewhat cynical about announcements such as these?

    Three years ago OH was diagnosed with atypical Alzheimers which indicates that the consultant was keeping his options open. GP believes he has some type of mixed dementia and the consultant has now arranged for further neuropsychological testing to see if he can clarify the diagnosis. So maybe we are going to give it a different name but the outcome will still be the same.

    Hope is a wonderful thing but false hope is tortuous.


    Life is pleasant. Death is peaceful. It's the transition that's troublesome.

    Isaac Asimov

  5. #20
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    The only thing left in the bottom of Pandora's box was HOPE.
    What will survive of us is love. ( Philip Larkin.)

  6. #21
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    I think the 'hope' is there for future generations. The enthusiasm of the scientists is that the research opens up a new way of tackling the disease....with new medicines or combinations of medicines. The academics have found two 'off the shelf' compounds (I initially thought only the Trazodone was already being prescribed but it could be both....the news get slightly distorted each time I watch the TV). These compunds in combination have an effect on mice that protects their brains. It isn't certain that the same effect will be seen in humans but they won't know until they do the trial. If the effect is positive then the drugs could be used quite quickly (apparently) but it won't reverse the brain damage of existing patients. Worse case is the drugs don't work in humans but the scientists will continue searching for existing and new compounds that do work in humans....the understanding of how they can protect the brain is just as important as the 'new' drug combination (that's the way I understand it). So hope is definitely on firmer ground.

  7. #22
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    Experience with Trazodone

    Thanks very much Kelvinl for your account of your experience with Trazodone. I have been thinking hard about whether to speak to our doctor about any potential benefits of this drug for my partner, and your experience gives a valuable perspective. Thanks again for sharing it.


    Quote Originally Posted by Kevinl View Post
    I'm sat here looking at a bottle of Trazodone right now, my wife was on it for quite a while. One dose at night and I could give her 2 doses during the day as required she still takes it now in the nursing home along with several other.
    It's usually given as needed to my wife but others seem to be on a scheduled dose from what I've seen.
    It did make her less aggressive which was when I usually used it but it also could make her disorientated and confused and definitely more of a fall risk even though that wasn't an issue at the time, only when she took the Trazodone, for that reason I used it as little as possible.
    She took it in conjunction with Donepezil and Citalopram which from what I was told by the nurse at the home was a pretty standard combination when she had a medication review late last year.
    K

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