New Drug Trial Seeks to Stop Alzheimer’s Before It Starts

[nmintueo]

New Drug Trial Seeks to Stop Alzheimer’s Before It Starts
http://www.nytimes.com/2012/05/16/he...rug-trial.html

[Canadian Joanne]

This is very interesting and I hope will prove to be useful. However, we do have to remember that it refers to people "guaranteed to develop AD", which means it is a focus on a particular EOFAD, Early Onset Familial Alzheimer's Disease, for which there is a test. The cases of this type of AD are less than 5% of all diagnosed with AD.

However, I think it's approaching the disease in the right way - preventing brain damage - and if successful in EOFAD, I'm certain they will extend the testing for sporadic AD, the most common kind.

[jenniferpa]

There's somethign a bit odd about that report. Well not the report exactly but it mentions that this drug Crenezumab is being used in a couple of other clinical trials, but I can't find those trials mentioned in the clinical trials database at all. It's possible it's named in the trials by a code number, but nothing really fits.

Incidentally hidden in the report was an indication that they are going to look again at inhaled insulin as a treatment for mild cognitive impairment.

This was the previous study on that treatment

http://www.ahaf.org/alzheimers/newsu...-may-slow.html

[BungleGirl]

Don't have time to read this propery and reply at the moment, but I just wanted to point out that the reason why those 'at risk' of FAD are ideal participants is because as they are younger, they are less likely to have other conditions that might make it more difficult to monitor the effects of the treatment.

There are more drugs trials in the pipeline which will use 'at risk' FAD participants as part of DIAN (will try to post the link later).

I also think that there is a very good 'take-up' from people at risk of FAD as obviously, we hope to be able to do something that may stop ourselves going through what our mother/father/aunts/uncles/grandparents went through, but almost more importantly stop other members of our family going through it. I can can cope with it happening to me but not to someone that I love.

I also believe that there is great hope that results of the FAD trials will benefit other forms of AD too.

Will pop back later when I'm not in such a rush. x

[Bodensee]

I read one of the comments underneath this story by a lady which has been flagged for saying that she thinks that there is a connection between Alzheimer's Disease & CJD. Perhaps it is just a matter of time before this will come out, I have read that Alzheimers's is indeed transmissable, could it actually be a prion disease? Just need some scientists to confirm this, its a global problem and rising in significant numbers and affecting younger people, it cant all be due to old age & inherited. And what is considered old age now 55?