Predicting Alzheimer disease and dementia
byon 24-10-2011 at 10:58 AM (699 Views)
[url=http://www.neurology.org/content/77/3/227.full.html]Nontraditional risk factors combine to predict Alzheimer disease and dementia.[/url][quote] Comprehensive re-evaluation of a well-characterized cohort showed that age associated decline in health status, in addition to traditional risk factors, is a risk factor for AD and dementia.
General health may be an important confounder to consider in dementia risk factor evaluation.
If a diverse range of deficits is associated with dementia, then improving general health might reduce dementia risk[/quote]
The full text of this paper is free online. I think the DISCUSSION section is well worth reading.
[quote] "[I]The cumulative effects of sometimes small and cognitively irrelevant insults is in general compatible with the idea that factors which take a toll on general bodily health also are associated with—or set up the conditions for—factors that give rise to dementia."[/I][/quote]
It's not a particularly easy message to get across but the fact that it may be the sum total of lot of smaller individual stresses that lead to the creation of the condition we diagnose as Alzheimer's is perhaps more in tune with reality and will ultimately be more productive than looking for THE CURE or THE REASON for the condition.
How to improve the overall health of the population so as to lessen the burden of late-life dementia seems to be the problem we need to solve and to keep repeating the errors of the last 30 years isn't going to help. .