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TedHutchinson

Alzheimer's disease-related peptides form toxic calcium channels in the plasma membra

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TedHutchinson
on 25-10-2011 at 02:57 PM (836 Views)
[url=http://jcb.rupress.org/content/early/2011/10/19/jcb.1953if.full?sid=c23f9f3f-2907-4882-9aee-aa25a97fbd0b]Imaging β amyloid's pore performance

Study visualizes Alzheimer's disease–related peptides forming toxic calcium channels in the plasma membrane.[/url]

[url=http://www.eurekalert.org/pub_releases/2011-10/rup-ssa101911.php]there is an article explaining this paper in more detail here.[/url]

Abstract here
[url=http://jcb.rupress.org/content/early/2011/10/19/jcb.201104133.abstract]Single-channel Ca2+ imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology[/url]

Bear in mind also that MAGNESIUM is a natural calcium channel blocker and most people don't consume the RDA for magnesium and most supplements only contain magnesium oxide of which only 4% is bioavailable. Remember also I've posted on the way Vitamin D and curcumin both help clear a beta from the brain. and melatonin stops it aggregating.

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Tags: a-beta, calcium
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  1. TedHutchinson's Avatar
    Here is a recent paper showing the way magnesium may be a good idea to for reducing the damaging consequences Ca(2+) induced neuroinflammation in degenerative neurological disorders such as Alzheimer disease and Parkinson disease.

    [url=http://www.ncbi.nlm.nih.gov/pubmed/21040713]Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels.[/url]

    and another
    [url=http://www.ncbi.nlm.nih.gov/pubmed/21951617]Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease.[/url] showing low levels of magnesium in AD patients and Mg-ion levels were significantly and directly related to cognitive function.